The Hodgkin and Huxley model has been previously discussed by philosophers of science, who have given different philosophical accounts of its epistemic achievements (Weber 2004, Craver 2007). The initial reflections on the Hodgkin and Huxley model were later criticized (Levy 2013, Pence 2017). However, none of the aforementioned discussions picks up on recent developments in neuroscience that tackle the extant recalcitrant evidence of the Hodgkin and Huxley model. In addition, new models have been developed that challenge many assumptions of the current accepted explanation.The project briefly presented here aims to bring this discussion up to date and reassesses the philosophical reflections of the Hodgkin and Huxley model in the light of new developments in neuroscience.